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The gencast network alert

  PODCAST: "Antibiotics Enhance RNAi Capabilities"

Peng Jin, Ph.D. Peng Jin, Ph.D., Assistant Professor, Department of Human Genetics, Emory University School of Medicine, is interviewed by GEN's Editor in Chief, John Sterling.

  WHEN: July 31—August 7, 2008

Researchers at the Emory University School of Medicine have discovered that fluoroquinolone antibiotics can make RNAi more effective in the laboratory and reduce potential side effects. The most powerful enhancer of RNAi was enoxacin, which has been used to treat gonorrhea and urinary tract infections. This group of compounds also includes the widely used antibiotic ciprofloxacin. The antibiotics' effect on RNAi appears to be chemically separate from their bacteria-killing activities.

During this week's GEN podcast, Dr. Jin talks about the role of RNAi as a research tool and its potential to treat a variety of diseases. He describes the experiments that led to the team's conclusions about antibiotics and RNAi and discusses the reasons why fluroquinolones are such effective therapeutics. He also reveals what makes enoxacin so useful in relation to RNAi.

Dr. Jin notes that significant barriers still prevent RNAi from working well in people and provides details on the research efforts aimed at overcoming these barriers.

LISTEN NOW to this week's GEN Podcast.

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About GEN
Genetic Engineering & Biotechnology News is the most widely read publication in the biotechnology industry and the only high-frequency publication focused on international bioindustry news. Established in 1981, GEN is also the first biotechnology trade publication, having covered the industry since its inception.

About Mary Ann Liebert, Inc. publishers
GEN is published by Mary Ann Liebert, Inc., a privately held, fully integrated media company known for developing authoritative, peer-reviewed journals in cutting-edge areas of bioscience and medicine, engineering, law, and business.

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